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If you are or will be breast-feeding while you use Allopurinol , check with your doctor. The mechanism is unknown and pharmacokinetic studies with hydrochlorothiazide have not demonstrated any effects on the disposition of allopurinol or oxipurinol (its major metabolite). Ask your health care provider if Allopurinol may interact with other medicines that you take. Unlike PURINETHOL (mercaptopurine) and IMURANŽ (azathioprine), Thioguanine may be continued in the usual dosage when allopurinol is used conjointly to inhibit uric acid formation. MetabolicKrasinger and colleagues suggest that it may be reasonable to add allopurinol to the pancreatic enzyme treatment regimen in CF patients that have a urine pH of less than 6 and also excrete large amounts of uric acid.
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